Hacker Newsnew | past | comments | ask | show | jobs | submit | more marcod's commentslogin

DEI is just their latest obsession, since the old ones don't poll as well anymore (gay marriage, woke, CRT, SJW, ..). I don't think there is a bigger rationale behind this than 'we need a wedge issue to rile up the masses'.


Exactly. Minorities are their scapegoats, it's not any more complex than that.


It's part of the Windows 11 24H2 update


Blinkenlights was always a fav of mine :)

ACHTUNG! ALLES TURISTEN UND NONTEKNISCHEN LOOKENSPEEPERS! DAS KOMPUTERMASCHINE IST NICHT FÜR DER GEFINGERPOKEN UND MITTENGRABEN! ODERWISE IST EASY TO SCHNAPPEN DER SPRINGENWERK, BLOWENFUSEN UND POPPENCORKEN MIT SPITZENSPARKEN. IST NICHT FÜR GEWERKEN BEI DUMMKOPFEN. DER RUBBERNECKEN SIGHTSEEREN KEEPEN DAS COTTONPICKEN HÄNDER IN DAS POCKETS MUSS. ZO RELAXEN UND WATSCHEN DER BLINKENLICHTEN.


Sorry for being nosy, but did you do oral immunotherapy with or without professional support?


With. First they did a blood test (instead of a scratch test) to identify possible allergy levels. Then the allergist had us come into the office to take e.g. a few micrograms of peanut powder and watch him for reactions. Then we maintained the dose at home every day for the next couple weeks, taking zyrtec with it to avoid hives, etc. Then we'd go back in, try doubling the dose as a challenge. If he had a bad reaction, we stayed on the same dose another few weeks, and if not, it became the new standard level. Rinse and repeat for about a year until we got to 2 peanuts, 1 cashew, and 1/4 tsp of tahini, which we maintained now for the past ~1.5y. We're due for another blood test and challenge here soon, as the allergist suggested there's a small chance that the immunotherapy could result in the allergies essentially receding


Our son is allergic to nearly everything (peanuts, nuts, dairy, eggs, sesame, wheat) and we haven't found an allergist willing to work with us. Do you know if there's an age factor for immunotherapy effectiveness? He's 2 1/2 yo.


Age is a known factor for oral immunotherapy’s risk and effectiveness, and the commonly cited fuzzy threshold is starting before 2 years of age. The data isn’t that strong, but “start very young” basically has practitioners’ consensus.

You have to shop around for allergists willing to do it. Our first allergist told us they weren’t comfortable doing it but it was becoming an increasingly popular option and referred us to several allergists who did it. We’ve also spoken to allergists who were bearish on it. It’s because there’s very little published data.


2 1/2 is right in the window, with the general consensus being that the earlier you start, the better the results. Studies found the best results with 1-year-olds, then it exponentially decreases with each year, until there's little benefit with 4+ year olds.

We did it with Latitude [1], with the support of our allergist, who had sent his son through them with successful results. It's not covered by insurance, and is expensive in all of time, money, and attention. The field is very new and data is still sparse - our allergist actually was very curious to hear results because he's adapting his practice as new data comes out from actual treatment.

[1] https://latitudefoodallergycare.com/


I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL

I looked into oral immunotherapy for tree nut allergies. There's a paper from 2022: https://onlinelibrary.wiley.com/doi/10.1111/all.15212

They did it in a few stages:

1. First three days: test the child with increasing amounts of cashew protein, until the child has a reaction. Use the amount ingested for that reaction, to determine the single highest tolerated dose (SHTD = the maximal amount of cashew protein each patient could tolerate).

2. Next 24 days: the child ingests the SHTD daily.

3. After that: every month, the dose was increased (I think at an in-person visit), and taken at home for the next 30 days.

For #1, I looked at the amounts of protein they gave the child. Table S2 (in one of the supporting documents) shows how much they gave on days 1, 2 and 3. Of course they stopped increasing once the child had a reaction. If you convert the amounts of protein into equivalent numbers of whole cashews, then you get:

- day 1: start with 1/1800th of a small cashew, increasing up to a fifth of a small cashew.

- day 2: 1/5th small cashew, up to 2 small cashews

- day 3: 2 small cashews, up to 22 small cashews

22 small cashews is about equivalent to what they want to achieve by the end of the therapy, i.e. if you don't have a reaction after eating that many, you won't have a reaction to a greater quantity.

It seems a bit hard to DIY it, because:

- The first three days requires very small amounts of cashew protein. At home we don't have either (i) isolated cashew protein, or (ii) tools to measure such small amounts (starting with 0.1mg cashew protein, or 0.5mg cashew).

- For the first three days, we'd need to be very vigilant to watch out for a reaction. I don't know whether, in a supervised setting, they'd observe or measure other factors than just an apparent reaction, to make sure the procedure is safe.

I AM NOT A DOCTOR OR OTHER HEALTHCARE PROFESSIONAL


For curiosity sake, curious if the tree nut allergy here was typical reactions (hives, nose, etc.)?

I have a tree nut "allergy" but doctors always call it more of a "hypersensitivity" because my reactions are usually involving terrible stomach cramps and pain accompanied occasionally by swollen throat (more so for almonds than cashews).

I've wondered if it's worth trying to do this myself.


Sounds like Oral Allergy Syndrome. I also have it with almonds and stone fruits.


Sudden loss of appetite, followed soon by nausea, and then vomiting.


Why wouldn’t you see the doctor? Cost? Not covered by insurance?


I have in the past but they weren't much of a help. Allergy scratch test results didn't correlate at all.

They referred me to a throat doctor to make sure it wasn't anything in my digestive system. So ended up doing an endoscopy. No notable findings there either.

So never been given any kind of ideas of things to try other than keeping a food journal, which has been useless to me.


for allergies most doctors are utterly useless. they either dont know the topic or the tests are unreliable and in the end you come out with no more info than you came in.


Ok I’ll bite - Wouldn’t have guessed it necessary to bookend a comment with all caps disclaimers, yet it’s happening, so I’m going to guess you have an interesting or cautionary anecdote around it we can possibly learn from?


Nope. Just being cautious!


>day 1: start with 1/1800th of a small cashew, increasing up to a fifth of a small cashew

do you mean, if there is no reaction to 1/1800th within minutes(?) then try 1/900th, lather rinse repeat?


Correct. The specifics are in the second page of this doc: https://onlinelibrary.wiley.com/action/downloadSupplement?do...

The intervals start at 10 minutes (start of day 1) and go to 90 minutes (start of day 3).

The dosage increments (in mg of cashew protein) start at 5x, but are mostly 1.5x or 2x.


Since you seem to be either a doctor or some other kind of healthcare professional can I ask what would you prescribe for aching butt?


Cortisone


Off topic. Anybody else like Thursday Next? Had to think of "Time waits for no man!"


Dolce&Gabbana Casa Leopard Silk & Wool Throw $3,245.00 - Purchased


The other good news of the day was that the Sackler family lost much of their future prosecution immunity

https://news.ycombinator.com/item?id=40813369


Always nice when a little bit of hope shines through the darkness.


Would you expect that kind of book to make any difference for final sentencing?


No, but it will make a difference in determining whether they're a flight risk by the judge. Given the evidence these two will probably await trail in jail rather than at home. Or at the very least they just bought themselves a nice new ankle bracelet.


The books evidence a desire to flee but equally evidence an ineptitude, the lack of an ability to flee. Buying a ticket for an international flight is akin to making an appointment with the FBI for you to be arrested. The FBI only dreams that every fugitive first pass through inspection/x-ray before being arrested in an airport terminal ringed with security. No need to worry about a fight, weapons or a dangerous police chase. The perps have already been frisked by the FAA. If these people ever run, they won't get far.


The FAA does not run airport security.

The FAA administers aviation, an actual necessary and valuable endeavor. The theatrical display you are subjected to in airports is overseen by DHS as justification for their continued existence as a jobs program. It has nothing to do with aviation.

But yes, the FBI would be happy to have fugitives be caught at an airport checkpoint, although I doubt they’d risk relying on DHS to do it.


At what point does a person’s purchase of an international flight ticket trigger an alert to LE?

Or does getting a notification like this require a warrant or similar court approval first?


I don't know that the system is all that great. I've known people with multiple warrants fly around and in/out of the country multiple times before finally getting stopped.


It's actually the TSA that does the frisking in the US at airports.


I can see it making a difference when presented to jury, if it's admitted as evidence. It may not be main evidence but combined altogether with other things they did, it might tilt the balance into the "sentence them closer the maximum term limit" vs the "lower end".


Judges not juries determine sentences in the US. In federal court the Guidelines are applied resembling nothing so much as a Pathfinder grapple roll.


convince jury


I feel like that is a separate effect... making you walk past items you might want to get you to buy them vs intentionally confusing you so you forget what you came in for in the first place, which makes you more susceptible the the previous and many other effects.


That explains why I'm always thinking about turtles ...

OK, not true, I'm thinking of a hedgehog, because the German version of Logo we used in the late 80s used an "Igel."


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: