I tried to switch to Dvorak and as an Emacs/Evil user I was really frustrated to have "easy" shortcuts like M-x, $, C-c C-f suddenly becoming cumbersome to perform (note that copy/cut/paste in everyday programs also became unwieldy).
How did you manage to get past that stage of "omg-why-is-everything-so-unfitting"?
I added dvorak as a regularly-used keyboard layout because of cramping issues while typing. Those went away immediately and never came back, so it was a win for me.