Chrome sandboxes Flash. If Flash is on your machine but disabled for Firefox, you can preserve the configurations that allowed this, and use Chrome as a dedicated Grooveshark / misc. Flash player. Depending on your arrangement, quitting Chrome can mean quitting Flash, so it can be a pretty elegant solution.

Hat-tip to Gruber for the idea http://daringfireball.net/2010/11/flash_free_and_cheating_wi....