Yes, that is simple. Finding out the first time why it suddenly stopped updating the config - after it already worked multiple times minutes before that - is a different matter.

I prefer the nuclear option, which also gives you a bit of a gamble depending on your search string

    pgrep tmux | xargs kill -9

`pkill -9 tmux` (or `pkill -9 [t]mux` if you're doing it over ssh)