That's not the problem. It's similar to the effect of a garden path sentence: when I encounter the word "a" and then "hypermedia", I'm always expecting something to follow (e.g. "a hypermedia system", "a hypermedia format", etc). Encountering "hypermedia" as a singular noun makes me wince.
(The effect isn't ameliorated by modifiers, e.g. "a natural hypermedia".)
