I really really hope [but doubt] Qubes OS runs on something like this with these caveats:

-using an add-in video card for dom0 gpu

-apple's on-die gpu can be passed through to a qube

-apple's unified memory does not need OS X to adjust the RAM/VRAM wall

Since I doubt these caveats are in play, I think I may be stuck with enterprise hand-me-downs that I can pass through.