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IIUC, it depends how the patient would lose that weight. Afaict, these drugs work by lowering appetite overall and making people poop out lots of food before it's fully digested. If the patient macros are still bad, the same proportions as before the drug, they'll have deficiencies such as protein, fiber, electrolytes, vitamins (esp fat-soluble ones), etc. But hopefully it's just for short term. (star)

So to get back to your question, one could lose the weight in the best possible way by correcting their diet, eating less, doing HIIT, fasting, good supplements like creatine, stress reduction through breath work and meditation, and resistance training and end up in a very strong position.

Please anyone correct me on this.

(star) Anecdote about my friend: He went on Metformin for a few years, had lots of diarrhea, and lost about 30 pounds and is skinnier than me. At this point, he could really really get into a strong health position having had that shortcut. His eating habits even got a little better from wearing a glucose monitor. He's sick of the diarrhea which really keeps him from wanting to be out of the house for long, and is slowly looking for some intriguing physical activities. So I think these drugs can help people.



> one could lose the weight in the best possible way by correcting their diet, eating less, doing HIIT, fasting

Yes, but actually doing that when you’re obese is extremely difficult and maintaining it is even harder than that. The best way I can describe how difficult, it’s like climbing Mt Everest and then discovering that you have to live up there. Lots of people do manage the climb, but staying up there is the real challenge and not a big percentage of people do. So, statements like yours while they’re technically true are ignorant of the biological and psycho-social dynamics of obesity, condescending (“why didn’t I think of just eating less!?”) and totally unhelpful.


I don't think HIIT or fasting is necessary. A workmate's father (BMI >> 40) went to BMI < 30 by getting a job as a security guard, and walking ten miles a night.

From my own hiking experience, that the first few days my appetite is suppressed, and similar reports from others, anthropomorphizing the body a bit it says "well, if we're going to be moving around this much, I don't want to carry all this weight".

Just walk.


> walking ten miles a night…From my own hiking experience

Is your plan sustainable through injury, and on vacation, and after being laid off and through holiday temptations, and through deep emotional turmoil, and just insidious calorie increases over time, and a million other real world scenarios that throw people off the wagon who have lifelong deep seated eating problems? This is so difficult for so many not because the obvious things work for everyone but because they don’t for a majority of people. We’ve tried all the obvious things!


Yes, yes it is.

If you're laid off you have more time to walk. If you're not walking that much quit your job and reduce your outgoings so that you can get a job that helps you survive past 45 without type 2 diabetes. Walking is very calming if you have emotional turmoil.

You don't get to a BMI that was much greater than 40 without eating disorders. Walking helps calm that, too.

I think people who say they have tried walking are lying to themselves. They're like the women who go to the gym and lift 2 lb dumbbells.

Walk ten miles a day for a year before telling me you've tried it.


> Walk ten miles a day for a year before telling me you've tried it.

Walking 10 miles a day isn't feasible for disabled and many injured people nor people who don't have 3+ hours spare to walk that far. If the principle is "do lots of exercise that you can do" yes we know about that, we've tried it many times, and the habit to sustain that didn't stick for the million and one reasons that they fail. Thankfully there are doctors and pharmaceutical companies that can understand recidivism statistics and don't just assume that obese people are morons or "lazy" or whatever ignorant and arrogant opinion you're espousing.


Is this backed by any science, btw? If it is just so simple there should be studies on it. Trying to make cheap and easy weight loss happen is one of the most well funded research arms.


Just because your friend's dad did it doesn't mean it's easy. It's not like everyone can just spend eight hours a night walking, and it also sounds like your friend's dad ate less just because he didn't have as much time to eat what he used to eat before.

"Become a security guard" isn't sustainable advice for weight loss.

Source: I work at a healthcare company that does weight loss, among other things.


Type 2 diabetes, hypertension and cardiovascular problems are the really unsustainable things here. Get your priorities straight.


Oh wow, that's such a great idea! We never tried telling people to get their priorities straight, but now that you mention it, it seems like such an obvious way to sustained weight loss! You're a genius!


Do you tell people in so many words, "you're going to die soon"?

The obsession with emotional safety that is prevalent these days is probably killing people.


Yeah, we do, and they know. The attitude of "if they just knew they shouldn't eat, their brain wouldn't be broken any more" is tiring, and, frankly, idiotic.

Maybe pull your head out of your ass long enough to realize that nobody wants to be fat under the immense societal pressure of random assholes telling them "you're going to die", and that poor self-control is actually a physical and mental issue.

This is like a tall person telling a short person "just reach higher! Ugh!".


But for two people who weigh the exact same to begin with, and eat the exact same after starting, does the person on the drug lose more muscle mass than the person not on the drug?


I don't think so based on personal experience. I'm losing weight on the drug because I'm eating less.

However, there is some science now to suggest that the body has other means of lowering BMI and reducing fat burn when it thinks it's starving (IE - any time it's losing weight). So it could be that my body not being in a panic is also helping to lose weight. But I'd bet it's largely just less calories.


* Er I meant BMR there. Too late to edit.


Hey friend, what’s IIUC stand for?


IIUC it stands for "If I understand correctly"




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