Overall, the incidence of cancer in the US among people under the age of 50 rose from 95.6 per 100,000 to 103.8 from 2000 to 2021.[ Colon cancer is one of the biggest drivers, but there are also a few others like kidney and thyroid that have seen big increases. Some of this, like thyroid cancer, might just be due to better detection of smaller, less serious cases. Fortunately, there are also some positive trends, like much lower rates of lung cancer (due to less smoking and cleaner air, presumably) and a decline in melanoma (skin) cancer after an increase in the early-to-mid 2000s (related to the rise and fall of tanning salons, I assume).