Copying the abstract here, just in case anybody don't have access:
Emily Austin, Hilary S. Myron, Richard K. Summerbell, Constance A. Mackenzie,
Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion,
Medical Mycology Case Reports, Volume 23, 2019, Pages 55-57, ISSN 2211-7539,
Abstract: Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin. On day 5 post-admission, he was discharged home. Outpatient follow-up confirmed complete resolution of his renal function.
Kind of a cool read. They're not really sure why the P. cubensis was nephrotoxic. The sample they put through mass spec didn't contain the compound (Orellanine) that the clinical presentation lined up with, and none of the other youths who ate from that crop of mushrooms had subsequent problems.
I wonder if there was an accidental polyculture issue, either with a different mushroom or a freak mutation that caused that particular shroom to synthesize toxic compounds. When growing directly from spores, you get mixed genetics, so your various mushrooms will grow slightly differently (if you want consistent genetics you grow clones from an isolate via agar plate or tissue sample from fruiting body).
Emily Austin, Hilary S. Myron, Richard K. Summerbell, Constance A. Mackenzie, Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion,
Medical Mycology Case Reports, Volume 23, 2019, Pages 55-57, ISSN 2211-7539,
https://doi.org/10.1016/j.mmcr.2018.12.007. (https://www.sciencedirect.com/science/article/pii/S221175391...)
Abstract: Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin. On day 5 post-admission, he was discharged home. Outpatient follow-up confirmed complete resolution of his renal function.
Keywords: Psilocybe; Nephrotoxicity; Mushrooms; Kidney injury