Beyond that what about protecting against latch-ups and bit flips due to radiation? The environment is significantly worse in space so short term faults and long term damage should be a concern. There's a reason why radiation hardened hardware uses chips with really large features.
Yeah I was wondering about that too, the far-greater exposure to radiation... I don't know anything about how well-mitigated that is these days, but I'm sure it's a huge factor they would have in mind?