It's mostly Mass Effect that's trouble under Proton. It requires the stupid EA launcher, which is trash. I have a Lenovo Legion Go S and getting it to work reliably is an absolute nightmare. Most other games I play are fine.
I just finished playing through Mass Effect Legendary Edition. Linux with Lutris. The EA Launcher gave me a few issues (like not launching sometimes), but it eventually worked. I did not have the game through Steam.
