Can be a bit dangerous on slick roads with no weight in the back.

Easy to hit things and people while turning if you're not used to the size, and even if you are.

Parts can be more expensive than one might think.

Couldn't agree more, due to their added size maintaining/operating a Silverado 1500 was similar to maintaining my Lexus. Reliable enough, but bigger tires, brakes, rotors, more fuel, etc.